A long-standing presence in the Atlanta entrepreneurial community, Eugene E. Houchins III leads American Life Fund Corp, a company that provides financial lifelines to people facing serious illnesses. Passionate about health and wellness, Eugene E. Houchins III has a particular interest in the prevention and treatment of cancer.
Anthracycline doxorubicin, a common chemotherapy drug, has one major drawback - its association with heart failure. A recent study by Washington State University researchers found that the protein FOXO1 plays a major role in heart damage.
FOXO1 acts as a transcription factor - a protein capable of binding to DNA and various genes and turning them on or off. Earlier research had shown a significant effect on the mass of the hearts of patients who took doxorubicin, with their hearts becoming smaller and endangering health.
Employing a rodent model, researchers demonstrated that with the use of FOXO1 inhibitor drugs, the damage could be suppressed. This resulted in the maintenance of heart cells and overall heart size and the prevention of doxorubicin-induced heart failure.
Anthracycline doxorubicin, a common chemotherapy drug, has one major drawback - its association with heart failure. A recent study by Washington State University researchers found that the protein FOXO1 plays a major role in heart damage.
FOXO1 acts as a transcription factor - a protein capable of binding to DNA and various genes and turning them on or off. Earlier research had shown a significant effect on the mass of the hearts of patients who took doxorubicin, with their hearts becoming smaller and endangering health.
Employing a rodent model, researchers demonstrated that with the use of FOXO1 inhibitor drugs, the damage could be suppressed. This resulted in the maintenance of heart cells and overall heart size and the prevention of doxorubicin-induced heart failure.
